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Prof. Xuhui HUANG

Research Interests | Teaching Assignments | Publications

Research Area

Protein Misfolding and Aggregation, Functional Conformational Changes in Transcription, Development of Kinetic Network Models for Long Timescale Dynamics.

Research Interests

Biophysical chemistry, Chemical biology, Physical and theoretical chemistry, Statistical mechanics, Structural biology,

Teaching Assignments

2020-21 Fall: CHEM5230 - Quantum Chemistry
2020-21 Spring: CHEM4691 - Capstone Research I
2020-21 Spring: SCIE1500 - Guided Study on Research I
2020-21 Spring: CHEM3420 - Physical Chemistry II
2020-21 Spring: CHEM5210 - Computational Chemistry
2019-20 Spring: SCIE4500 - IRE Research Project II
2019-20 Spring: CHEM4691 - Capstone Research I
2019-20 Spring: CHEM3420 - Physical Chemistry II

Recent Publications


  • Zhang, Lu; Zhang, Dong; Wang, Xiaowei; Yuan, Congmin; Li, Yongfang; Jian, Xilin; Gao, Xin; Yen, Hui-Ling; Cheung, Pak Hang Peter; Huang, Xuhui, "1′-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication", (2021)
  • Konovalov, Kirill; Wang, Wei; Wang, Guo; Goonetilleke, Eshani Chrisana; Gao, Xin; Wang, Dong; Huang, Xuhui, "A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models", (2021)
  • Cao, Zhe; Wang, Xiaowei; Huang, Xuhui; Mak, Ho Yi, "Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system", (2021)
  • Cheung, Carina Hey Pui; Xu, Jianchao; Lee, Chi Lung; Zhang, Yanfeng; Wei, Ruohan; Bierer, Donald; Huang, Xuhui; Li, Xuechen, "Construction of diverse peptide structural architectures: Via chemoselective peptide ligation", (2021)
  • Wang, Xiaowei; Unarta, Ilona Christy; Cheung, Pak Hang Peter; Huang, Xuhui, "Elucidating molecular mechanisms of functional conformational changes of proteins via Markov state models", (2021)

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