RPG Student List

 

Ning ZHAN

Doctor Candidate in Chemical and Biomolecular Engineering

Supervisor: Prof. King Lun YEUNG

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Research Topic

High-intensity Narrow-wavelength (Hi-NW) Light-based Technology for Surface Disinfection

Abstract

Hospital-acquired infections (HAI) are becoming important causes of mortality and morbidity in hospitals. Multi-drug Resistant Organisms (MDROs) cause the majority of nonsocial infections. Hi-NW light-based Technology provides an alternative technology, which is safe and effective against a wide spectrum of microorganisms without the emergence of microbial resistance. This technology based on the combined use of focused LED lighting sources to assemble a light array to target multiple sites within the microbe for rapid in decontamination of MDROs commonly found in hospital environments. Multiple cellular targets and different inactivation pathways ensure that microbial tolerance and resistance are avoided. High intensity 405nm, 470nm and 275nm LED are employed and assembled into 3*3 LED array. The bactericidal rate of E.coli, P.aeruginosa, S.aures and E.faecalis., which are as surrogate for their MDRO counterparts, are 4-log (99.99%) reduction within 10mins. The morphology of testing bacteria was analyzed by scanning electron microscope. Recent experiments revealed that the bactericidal effect on MDROs (i.e., MRSA, MRPA, VRE, and CRE) were 4-log (99.99%) reduction within 10mins as well. This technology can provide high bactericidal effect on MDROs and complement existing hospital practice to address an important public health problem.

Journal Publication


Zhan, Ning; Dy, Trixie Ruth Nunez; Kwan, Joseph Kai Cho; Yeung, King Lun, "Bactericidal activity and design of low voltage Pulsed-Electric Field (PEF) device for water disinfection", (2017)
 
Zhan, Ning; Chang, Qing; Yeung, King Lun, "Bactericidal activity and mechanism of high intensity narrow wavelength blue light LED", (2017)
 
Zhan, Ning; Chang, Qing; Wong, Nga Ki; Yeung, King Lun, "Design a bactericidal system with High-intensity Narrow-Wavelength (Hi-NW) LED to eliminate the environmental pathogen and biosafety studies of the system", (2017)
 
Lee, Jong Hong; Zhan, Ning; Kwan, Joseph K.C.; Yeung, King Lun, "Design air purification filters with formulated antimicrobial agents", (2017)
 
Zhan, Ning; Chang, Qing; Yeung, King Lun, "Design and practice of a long-term bactericidal system", (2017)
 
Zhan, Ning; Chang, Qing; Yeung, King Lun; Kwan, Joseph K.C., "Mechanism of an antimicrobial surface agent and virucidal efficiency", (2017)
 
Li, Ying; Yeung, King Lun; Zhan, Ning, "Control of Nanofiltration membranes biofouling by using a new anti-fouling coating", (2016)
 
Chang, Qing; Zhong, Baihua; Zhan, Ning; Wong, Nga Ki; Yeung, King Lun, "Investigation of the light disinfection of multidrug-resistant microorganisms", (2016)