RPG Student List

 

Ghodsiehsadat JAHANMIR

Doctor Candidate in Chemical and Biomolecular Engineering

Supervisor: Prof. Ying CHAU

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Research Topic

In Situ Gel for Ocular Drug Delivery: Synthesis, Characterization and Mathematical Modelling

Abstract

Eye, as one of the vital organs of the body is protected by a variety of biological mechanisms against pathogens. So with these static and dynamic barriers, effective drug delivery to ocular tissues in sight-threatening diseases such as age-related macular degeneration and diabetic retinopathy is not easy. Also current clinical practice such as an injection into the eye are invasive and need frequent injections associated with many side effects. The objective of the proposed project is to develop a novel in situ biodegradable hydrogel-based controlled release ocular drug delivery depot with active functional groups through Michael addition reaction. To evaluate the efficacy of our formulation, drug release and mass loss profiles and also biocompatibility of the gel toward the eye tissues will be determined. To decrease the experimental expenses, a mathematical model will be provided for prediction of drug distribution in different tissues after injection using computational fluid dynamics techniques.

Journal Publication


Lau, Chi Ming Laurence; Yu, Yu; Jahanmir, Ghodsiehsadat; Chau, Ying, "Controlled release technology for anti-angiogenesis treatment of posterior eye diseases: Current status and challenges", (2018)
 
Jahanmir, Ghodsiehsadat; Abdekhodaie, mohammad j; Chau, Ying, "Stochastic Modeling of Degradation Behavior of Hydrogels", (2018)
 
Lau, laurence c.m.; Jahanmir, g.; Yu, Yu; Chau, Ying, "Injectable, Degradable Dextran Based Hydrogel for Long Term Intraocular Macromolecular Therapeutics Delivery", (2017)
 
Jahanmir, g.; Lau, laurence c.m.; Yu, Yu; Chau, Ying, "Stochastic Modeling of Macromolecular Therapeutics Delivery from Hydrolytically Degradable Hydrogel Depot", (2017)
 
Jahanmir, Ghodsiehsadat; Chau, Ying, "Computational Modeling of Therapeutic Protein Distribution in the Rabbit Eye", (2016)
 
Jahanmir, Ghodsiehsadat; Addekhodaie, M.J.; Chau, Ying, "Modelling and controlling degradation and protein release profile from degradable polymer-polymer hydrogel depot", (2016)